Mathematical modeling of calcium signaling during sperm hyperactivation
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چکیده
منابع مشابه
Mathematical Modeling of Calcium Signaling in Sperm Mathematical modeling of calcium signaling during sperm hyperactivation
Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the cumulus matrix. It is absolutely required for sperm penetration of the oocyte zona pellucida. In order for sperm to hyperactivate, cytoplasmic Ca level...
متن کاملMathematical modeling of calcium signaling during sperm hyperactivation.
Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the cumulus matrix. It is absolutely required for sperm penetration of the oocyte zona pellucida. In order for sperm to hyperactivate, cytoplasmic Ca(2+) l...
متن کاملBehavioral Mechanism during Human Sperm Chemotaxis: Involvement of Hyperactivation
When mammalian spermatozoa become capacitated they acquire, among other activities, chemotactic responsiveness and the ability to exhibit occasional events of hyperactivated motility--a vigorous motility type with large amplitudes of head displacement. Although a number of roles have been proposed for this type of motility, its function is still obscure. Here we provide evidence suggesting that...
متن کاملControl of hyperactivation in sperm.
BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus. Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending. ...
متن کاملThe clinical significance of calcium-signalling pathways mediating human sperm hyperactivation
STUDY QUESTION What is the prevalence of defects in the Ca(2+)-signalling pathways mediating hyperactivation (calcium influx and store mobilization) among donors and sub-fertile patients and are they functionally significant, i.e. related to fertilization success at IVF? SUMMARY ANSWER This study identifies, for the first time, the prevalence of Ca(2+) store defects in sperm from research don...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2011
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gar040